The most important positive effects of statins are anti-inflammatory, anti-proliferative, antioxidant, immunomodulatory, neuroprotective, anti-diabetes, and antithrombotic, improving endothelial dysfunction and attenuating vascular remodeling besides many others which are discussed under the scope of this review.

Pleiotropic effects of medicines are generally beneficial. For instance, aspirin was originally used as a pain reliever and was later found to have the pleiotropic effect of lowering the risk of heart attack. Statin drugs have pleiotropic effects, which is one reason the medical community is so enthusiastic about them.

Circulation. renal effects of glucagon like peptide 1 analog and peptidyl Peptidase-4 inhibitor in rats. Cardiovasc [PubMed]. 20.

2005;111(18):2356-63. 16. Robinson JG, Smith International conference. Abbott, J. K. & Tazzyman, S. J. (2016) Pleiotropic effects on investment permit the maintenance of polymorphic sexually antagonistic av N Ausmees · 2007 · Citerat av 59 — Deletion of smeA-sffA gave rise to pleiotropic effects on spore maturation, and influenced the segregation of chromosomes and placement of septa during 14 nov.

The pleiotropic effects attributed to statins are many. 1,2 They include increases in endothelial nitric oxide formation; flow-mediated vascular dilatation; suppression of vascular inflammation; reduction of circulating biomarkers that indicate inflammation (such as C-reactive protein); a reduction in T-cell activation with a decrease in cytokines; promotion of neovascularization in ischemic tissue; and …

Signaling is initiated by ligand-specific activation of cell surface receptors with … Definition of pleiotropic. : producing more than one effect especially : having multiple phenotypic expressions a pleiotropic gene. Pleiotropic effects mediated by inhibition of isoprenoids correlate with the inhibition of cholesterol biosynthesis and are difficult to quantitate. Regulatory agencies require that new cholesterol-lowering treatments should be tested on top of background standard of care therapy, including statins.

Pleiotropic effects stem from both normal and mutated genes, but those caused by mutations are often more noticeable and easier to study. Pleiotropy is actually more common than its opposite, since in a complex organism, a protein from a single gene is likely to be expressed in more than one tissue, and the cascade of problems caused by a mutation is likely to lead to numerous complications

Circulation. renal effects of glucagon like peptide 1 analog and peptidyl Peptidase-4 inhibitor in rats. Cardiovasc [PubMed].

Author information: (1)Stem Cell Signalling Laboratory, Department of Development and Regeneration, KU Leuven Stem Cell Institute, Herestraat 49, Onderwijs en Navorsing 4, Box 804, 3000 Leuven Pleiotropic: Producing or having multiple effects from a single gene.
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Regulatory agencies require that new cholesterol-lowering treatments should be tested on top of background standard of care therapy, including statins. An analysis published in the Annals of Internal Medicine in 2018 found pleiotropic benefits were not significant. Good overview of pleiotropic effects. Statins may have good effects for Alzheimer's and Parkinson's disease, infection management, and traumatic brain injury and spinal cord injury.

Pleiotropic effects mediated by inhibition of isoprenoids correlate with the inhibition of cholesterol biosynthesis and are difficult to quantitate. Regulatory agencies require that new cholesterol-lowering treatments should be tested on top of background standard of care therapy, including statins.
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2019-09-24

Regulatory agencies require that new cholesterol-lowering treatments should be tested on top of background standard of care therapy, including statins. Pleiotropic effects are most commonly noticed in conjunction with genetic disorders, since a mutation on a single gene may result in multiple problems affecting growth and development, i.e., height, weight, skeletal development.

The most important positive effects of statins are anti-inflammatory, anti-proliferative, antioxidant, immunomodulatory, neuroprotective, anti-diabetes, and antithrombotic, improving endothelial dysfunction and attenuating vascular remodeling besides many others which are discussed under the scope of this review.

Statins are are also Se hela listan på academic.oup.com Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Moeller BJ(1), Dreher MR, Rabbani ZN, Schroeder T, Cao Y, Li CY, Dewhirst MW. Author information: (1)Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA. Comment in Cancer Cell. 2005 Aug;8(2):89-91. Cancer Cell.

Pleiotropic preventive effects of dietary polyphenols in cardiovascular diseases. Y Kishimoto 1, M Tani 1 & K Kondo 1 Pleiotropic Effects of GIP on Islet Function Involve Osteopontin. Research output: Contribution to journal › Article Welcome to the Goodman Learning. In this video Dr. Sean McManus explains the genetic concept of pleiotropy.We explore the concept of pleiotropy with specific The pleiotropic effects of vitamin D and associated mechanisms are summarized in Table 1. In addition, the paracrine and autocrine effects of vitamin D have a protective role in many diseases. Therefore, the application of vitamin D in disease treatment and prevention should be pursued.